Capsid Engineering Discovery and Preclinical Manufacturing Operations

UNLOCKING THE POTENTIAL OF GENE THERAPY FOR ALL

FULLY INTEGRATED Clinical Development

UNLOCKING THE POTENTIAL OF GENE THERAPY FOR ALL


About

Capsida Biotherapeutics is developing next generation, targeted genetic medicines for rare and more common neurological and ocular diseases across all ages.


Pipeline

Our Pipeline is Making the Impossible Possible

Capsida’s gene therapies utilize proprietary engineered capsids for the CNS and eye that enable high transduction levels in desired tissues and cells and are designed to limit traditional gene therapy safety concerns such as liver and dorsal root ganglion (DRG) toxicity and ocular inflammation.

We are developing an investigational therapy for STXBP1-developmental and epileptic encephalopathy (STXBP1-DEE) and an investigational therapy for Parkinson’s disease associated with GBA mutations (PD-GBA). We are also developing an investigational therapy for Friedreich’s ataxia (FA), which is currently in IND-enabling studies and aiming to target CNS, cardiac, and sensory manifestations with a single IV infusion.

For diseases of the eye, Capsida is directing its platform to engineer capsids for local intravitreal (IVT) and suprachoroidal (SCS) delivery.


Science & Innovation

THE CAPSIDA APPROACH

Capsida integrates all capabilities needed to surpass the challenges of gene therapy.

graphic

Capsid Engineering and Preclinical

At Capsida, the scale at which we have engineered capsids is unrivaled. Using our fully industrialized and roboticized screening method, our scientists assess large, diverse engineered capsid libraries for CNS and the eye in non-human primates to quickly identify optimal capsids for disease targets. To quickly advance our mission of providing meaningful therapeutic opportunities for patients with unmet medical need, Capsida characterizes the novel mechanisms of action that enable our engineered capsids to cross biological barriers, optimizes cargo and evolves preclinical disease proof-of-concept in parallel with capsid engineering. Our engineered capsids can be optimized to deliver a broad range of cargo modalities.

graphic

Manufacturing Operations

We have built state-of-the-art cGMP manufacturing capabilities to perform everything in-house. We streamline the entire process, from selecting our therapies for manufacturability through scalable process development. Ultimately, this helps us get therapeutics to patients sooner.


Team

Capsida’s founding technology originated in the lab of Caltech’s Viviana Gradinaru, Ph.D., Professor of Neurosciences and Biological Engineering at the Tianqiao and Chrissy Chen Institute of Neuroscience. Founded in 2019, Capsida is financed by Versant Ventures and Westlake Village BioPartners and has entered into strategic collaborations with AbbVie, CRISPR Therapeutics, and Lilly’s Gene Therapy Division.

Our leaders have decades of experience in the biopharmaceutical industry and expertise in AAV biology and biologics manufacturing.


Partnering

“Our partnerships with leading global biopharmaceutical companies are key to Capsida achieving its vision of being able to reach more potential patients in need with our enabling genetic medicines.”

Bethany Mancilla, Chief Business Officer

Our goal is to apply the strength of our targeted genetic medicine platform to develop a new generation of transformative therapies. Since our inception, we have entered into strategic collaborations with AbbVie, CRISPR Therapeutics, and Lilly’s Gene Therapy Division.

Learn More

Careers

BE PART OF OUR DNA

Capsida is a vibrant company based in the heart of the Greater Los Angeles biotech hub. We’re looking for passionate, dedicated colleagues to join us!

Learn More

News & Events

CAPSIDA NEWS & EVENTS

An Important Update Regarding Our CAP-002 Program: A Letter to the STXBP1 Community

To the STXBP1 Community: The team at Capsida is very aware that the STXBP1 community is anxious to learn more about the unexpected and devastating loss of the…

A Letter to the STXBP1 Community

To the STXBP1 Community: It is with heavy hearts that we share that the first patient to participate in our SYNRGY trial for STXBP1-Related Disorders passed…

Privacy Preference Center